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当归和川芎一直是中医治疗痛经和月经不调的良药,其中的油类成份(ligustilidebutylidenephthalide,butyphthalide等)具中枢抑制作用、抗痉挛及松驰子宫的作用,曾有报道,川芎的有效成分四甲基吡嗪(TMP)及当归的有效成分阿魏酸(FA)具有抑制心脏兴奋、血小板聚集、血栓素A_2的生物合成及扩张冠脉的作用,然而,对子宮自发活动的影响则很少报道,本文研究厂TMP及FA对动情期大鼠在体子宫的白发活动的影响,以及TMP和FA的协同效应。口服TMP、FA和罂粟碱对大鼠子宫自动收缩频率和幅度均有抑制作用并呈现剂量依赖关系,TMP 100mg/kg使收缩力下降
Angelica and Chuanxiong have been traditional medicines for the treatment of dysmenorrhea and irregular menstruation. Among them, oil components (ligustilidebutylidenephthalide, butyphthalide, etc.) have a central inhibitory effect, antispasmodic and relaxant uterus. It has been reported that Chuanxiong active ingredients are Glyphosate (TMP) and the effective component of angelica ferulic acid (FA) have the effects of inhibiting cardiac excitability, platelet aggregation, biosynthesis of thromboxane A 2 and dilation of coronary artery, however, the effect on spontaneous activity of the uterus is rarely reported. The effects of TMP and FA on the white hair activity of the uterus in estrus rats and the synergistic effects of TMP and FA were studied in this study. Oral administration of TMP, FA, and papaverine inhibited both the frequency and amplitude of rat uterine contractions in a dose-dependent manner. TMP 100 mg/kg decreased contractility.