吡喹酮是目前临床常用的广谱抗寄生虫药,经临床实践证明,该药毒性低、疗效高、疗程短、对血吸虫、囊虫等均有特效。 吡喹酮临床药代动力学研究在国外早有报导。本文对国产吡喹酮片剂及北京第三制药厂新近研制的吡喹酮注射剂进行了临床药代动力学研究及两种制剂的生物利用度比较。 Praziquantel is currently widely used in clinical broad-spectrum antiparasitic drugs, clinical practice has proved that the drug is low toxicity, high efficacy, short course of treatment, have effects on schistosomes, cysticercosis and so on. Praziquantel clinical pharmacokinetics has long been reported in foreign countries. In this paper, the domestic pharmacokinetics of praziquantel tablet and praziquantel injection newly developed by Beijing No. 3 Pharmaceutical Factory were studied and the bioavailability of the two preparations was compared.