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将氨基锌酞菁(ZnTAPc)与甲基丙烯酰氯反应制备出含有不饱和双键的取代锌酞菁衍生物(MeZnAPc),采用ATRP法将聚乙二醇单甲醚大分子引发剂(mPEG110-Br)与甲基丙烯酸(2-异丙胺基)乙酯(DPA)和MeZnAPc共聚,制得一种新型pH响应两亲嵌段锌酞菁聚合物光敏剂(PEG110-b-P(DPAn-co-MeZnAPcm)).用1HNMR,FTIR对MeZnAPc和聚合物光敏剂进行表征.UV-vis测试表明该聚合物光敏剂在pH6.0～6.5具有较好的pH响应性.以1,3-二苯基苯并呋喃(DPBF)为底物研究了该聚合物光敏剂的光催化氧化效率,结果表明其具有较高光活性.利用该聚合物光敏剂在不同pH的水溶液中对L-色氨酸进行光催化氧化实验,结果发现在pH5.5不存在胶束时,锌酞菁可以较好地分散在溶液中,并能维持较高光活性,而在pH7.4形成胶束时可以将锌酞菁很好地包裹在其内部,使其光活性大大降低.因此,这种pH响应两亲嵌段锌酞菁聚合物作为一种新型光敏剂,在光动力学治疗领域有较好的应用前景.
Amino-zinc phthalocyanine (ZnTAPc) was reacted with methacryloyl chloride to prepare a substituted zinc phthalocyanine derivative (MeZnAPc) containing unsaturated double bonds. A polyethylene glycol monomethyl ether macromolecular initiator (mPEG110- (DPAn-co-MeZnAPcm) was prepared by copolymerization of 2-isopropylaminoethyl methacrylate (DPA) and MeZnAPc )). MeZnAPc and polymeric photosensitizers were characterized by 1HNMR and FTIR.UV-vis showed that the photosensitizers had good pH response at pH 6.0 ~ 6.5. The 1,3-diphenylbenzene Furan (DPBF) as a substrate, the photocatalytic oxidation efficiency of the photosensitizer was studied, and the results showed that the photosensitizer had higher photoactivity.L-tryptophan was photocatalyzed by aqueous solution of different pH Oxidation experiments and found that in the absence of micelles at pH 5.5, zinc phthalocyanine is well dispersed in solution and maintains high photoactivity, whereas zinc phthalocyanine is very good when micelles are formed at pH 7.4 So that its photo-activity is greatly reduced.Therefore, this pH-responsive amphiphilic zinc phthalocyanine polymer as a new type of photosensitizer , In the field of photodynamic therapy has a better application prospects.