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雷米普利(Ramipril)为一高效、长效血管紧张素转化酶(ACE)抑制剂。本品是一个前体药物,活性代谢产物为雷米普利拉。本品竞争性结合于ACE,先形成一种酶抑制剂复体,再异构化成一种分解率缓慢的复体。吸收率和生物利用度:空腹口服本品后1小时原形药物吸收达峰浓度。Badian等证明,口服本品胶囊10mg后2.1±0.9小时达到活性雷米普利拉浓度;如在早餐后口服,则达该浓度时间稍延迟(2.7±1.4小时)。生物利用度大约60%。
Ramipril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor. This product is a prodrug, the active metabolite is ramipril. This product competitively combined with ACE, first form an enzyme inhibitor complex, and then isomerization into a complex decomposition rate slow complex. Absorption rate and bioavailability: 1 hour after oral administration of crude drugs prototype drug absorption peak concentration. Badian and other evidence, oral administration of this product capsule after 10 ± 2.1 ± 0.9 hours to reach the active concentration of ramipril; such as after oral administration, then the concentration of a little delayed (2.7 ± 1.4 hours). Bioavailability is about 60%.