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肿瘤的多药抗药性(MDR)的主要作用机制与抗药细胞浆膜上的P糖蛋白(P-gp)的过分表达有关,P-gp作为能量依赖性泵,降低抗癌药在细胞内的积聚。在寻找与P-gp相互作用的化合物中,发现孕酮和有些甾类化合物等可增加MDR细胞对抗肿
The main mechanism of action of multidrug resistance (MDR) in tumors is related to the overexpression of P-glycoprotein (P-gp) on the resistant cytoplasm. As an energy-dependent pump, P-gp reduces the intracellular The accumulation of. In looking for compounds that interact with P-gp, progesterone and some steroids are found to increase MDR cell resistance