目的：研究氧化型低密度脂蛋白（ｏｘＬＤＬ）对单核细胞与血管内皮细胞粘附作用．方法：用超速离心方法分离健康人血浆低密度脂蛋白，以１０μｍｏｌ·Ｌ－１ＣｕＳＯ４氧化．观察ｏｘＬＤＬ对人外周血单核细胞（ＭＣ）与小牛主动脉血管内皮细胞（ＢＡＥＣ）粘附作用的影响．结果：ｏｘＬＤＬ能以时间和剂量依赖性方式促进ＭＣ与ＢＡＥＣ粘附作用．放线菌酮Ｄ和ｓｔａｕｒｏｓｐｏｒｉｎｅ（Ｓｔａ）能取消这种促进作用，但硫酸葡聚糖对此作用无影响．ＰＭＡ和６μｍｏｌ·Ｌ－１溶血性磷酯酰胆硷也显著增强ＭＣ与ＢＡＥＣ的粘附作用，且此增敏作用也可被Ｓｔａ取消．结论：ｏｘＬＤＬ能通过激活蛋白激酶Ｃ促进ＭＣ与ＢＡＥＣ的粘附作用． Objective: To investigate the effect of oxLDL on the adhesion of monocytes to vascular endothelial cells. Methods: Healthy human plasma LDL was isolated by ultracentrifugation and oxidized with 10μmol·L-1CuSO4. To observe the effect of oxLDL on the adhesion of human peripheral blood mononuclear cells (MCs) to bovine aortic endothelial cells (BAECs). Results: Ox LDL can promote the adhesion of MC and BAEC in a time and dose-dependent manner. Cycloheximide D and staurosporine (Sta) abolished this promotion, but dextran sulfate had no effect on this effect. PMA and 6 μmol·L-1 hemolytic phosphatidyl choline also significantly enhanced the adhesion of MC to BAEC, and this sensitization was also canceled by Sta. Conclusion: OxLDL can promote the adhesion of MC and BAEC by activating protein kinase C.