新生儿动脉导管的关闭是一个自然的过程,随着肺呼吸功能的建立,肺血流阻力下降,动脉血氧饱和度迅速上升,血管活性物质的释放等使动脉导管发生收缩关闭。动脉导管关闭分为两期,第一期为生理性关闭或功能性关闭,研究证实几乎所有的足月儿在生后72 h左右动脉导管即完成功能上的关闭,而 Neonatal patent ductus arteriosus closure is a natural process. With the establishment of respiratory function of the lungs, the resistance of the pulmonary blood flow drops, the arterial oxygen saturation rises rapidly, and the release of vasoactive substances causes the patent ductus arteriosus to contract and close. Arterial catheter closure is divided into two phases, the first phase of the physiological closure or functional closure, the study confirmed that almost all of the full-term infants around 72 h after birth to complete the functional catheter closure, and