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CUTL1又称CDP,Cut,Cux,属于同源框异型盒转录因子家族,参与细胞的生长、分化和发育,并参与许多细胞基因的转录调节。CUTL1在髓性增生性疾病,卵巢肿瘤中存在杂和性缺失,在子宫平滑肌瘤,胰腺癌和乳腺癌中表达有增高。CUTL1为TGFβ信号转导通路的一个靶标,介导TGFβ的促迁移活性并在促进细胞运动和肿瘤细胞侵袭性生长方面发挥重要作用。
CUTL1, also known as CDP, Cut, and Cux, belongs to the family of homeobox transcription factors and is involved in the growth, differentiation and development of cells and is involved in the transcriptional regulation of many cellular genes. CUTL1 is a missense deficiency in myeloproliferative disorders and ovarian tumors and is expressed in uterine leiomyomas, pancreatic and breast cancers. CUTL1, a target of the TGFβ signaling pathway, mediates the pro-migration activity of TGFβ and plays an important role in promoting cell motility and tumor cell invasive growth.