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目的:观察大剂量环磷酰胺冲击疗法联合低剂量泼尼松治疗紫癜性肾炎的疗效。方法:38例紫癜性肾炎患儿分为2组,观察组21例给予大剂量环磷酰胺冲击疗法联合低剂量泼尼松,对照组17例给予足量泼尼松。比较2组疗效,治疗前后血浆总蛋白、白蛋白、24 h尿蛋白定量。结果:2组治疗后血浆总蛋白和白蛋白均高于治疗前(P<0.05),24 h尿蛋白定量低于治疗前(P<0.01)。观察组各指标改善优于对照组(P<0.05或P<0.01)。总有效率观察组(81.0%)高于对照组(64.7%)(P<0.05)。结论:大剂量环磷酰胺冲击疗法联合低剂量泼尼松治疗紫癜性肾炎疗效确切。
Objective: To observe the effect of high-dose cyclophosphamide shock therapy combined with low-dose prednisone in the treatment of purpuric nephritis. Methods: Thirty-eight children with purpura nephritis were divided into two groups. 21 cases in the observation group were given high dose cyclophosphamide combined with low dose prednisone, and 17 cases in the control group were given enough prednisone. The curative effect of two groups were compared. The total plasma protein, albumin, 24 h urine protein before and after treatment were quantified. Results: The total protein and albumin of plasma in both groups were higher than those before treatment (P <0.05), and the levels of 24 h urine protein were lower than those before treatment (P <0.01). The observation group improved better than the control group (P <0.05 or P <0.01). The total effective observation group (81.0%) was higher than the control group (64.7%) (P <0.05). Conclusion: High-dose cyclophosphamide shock therapy combined with low-dose prednisone is effective in purpura nephritis.