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目的通过测定早产及足月产患者母血清内皮素-1(ET-1)的水平,探讨其与早产及分娩发动的关系。方法将研究对象分为足月妊娠组,包括足月妊娠未临产组及足月妊娠临产组,未足月组包括先兆早产24 h分娩者,24 h未分娩者及对照组,用放射免疫法测患者母血清ET-1水平。结果①足月临产组ET-1水平较足月未临产组高;②与对照组比较先兆早产组ET-1均升高,其中24 h分娩者ET-1水平高于24 h未分娩者。结论 ET-1可直接促进分娩发动,它的升高可预示临产的发生。
Objective To determine the level of endothelin-1 (ET-1) in maternal serum of preterm and full-term patients and explore its relationship with premature labor and labor onset. Methods The subjects were divided into full-term pregnancy group, including full-term non-labor group and full-term labor group. Insubstantial group included 24 hours delivery for threatened preterm labor, 24 hours non-delivery group and control group. Radioimmunoassay Patient serum ET-1 levels were measured. Results ① The level of ET-1 in full-term labor group was higher than that in full-term non-labor group. (2) Compared with control group, the ET-1 level in preterm labor group was increased. Conclusion ET-1 can directly promote the onset of labor, and its rise may indicate the occurrence of labor.