目的　探讨乌拉地尔与多巴酚丁胺、多巴胺合用治疗急性左心衰竭的效果及安全性。方法　 93例急性左心衰竭患者 ,随机分为A、B、C 3组 ,每组各 31例。A组为对照组 ,予常规治疗 ;B组为乌拉地尔治疗组 ,在同A组常规治疗的基础上加用乌拉地尔治疗 ;C组为联合治疗组 ,在同A组常规治疗的基础上 ,加用乌拉地尔、多巴酚丁胺、多巴胺、速尿合用治疗。结果　A组显效 8例 ,有效 13例 ,无效 10例 ,总有效率 6 7 7% ;B组显效 19例 ,有效9例 ,无效 3例 ,总有效率 90 3 % ;C组显效 2 7例 ,有效 3例 ,无效 1例 ,总有效率 96 8%。A组与B组比P <0 0 1,A组与C组比P <0 0 0 1。结论　乌拉地尔治疗急性左心衰竭效果显著 ,与多巴酚丁胺、多巴胺、速尿联合应用效果更佳、更安全 ,可作为急性左心衰竭的常规治疗。 Objective To investigate the efficacy and safety of urapidil combined with dobutamine and dopamine in the treatment of acute left heart failure. Methods Ninety-three patients with acute left heart failure were randomly divided into A, B and C groups, with 31 cases in each group. A group as control group, conventional treatment; B group for the urapidil group, with the conventional treatment of group A plus Urapidil treatment; C group for the combined treatment group, with the same group A conventional treatment based On the plus use of urapidil, dobutamine, dopamine, furosemide combined treatment. Results In group A, 8 cases were markedly effective, 13 cases were effective, 10 cases were ineffective, and the total effective rate was 67.7%. In group B, 19 cases were markedly effective, 9 cases were effective, 3 cases were ineffective, and the total effective rate was 90.3%. 3 cases were effective, 1 case was ineffective, and the total effective rate was 96.8%. A group and B group P <0 0 1, A group and C group P <0 0 0 1. Conclusion Urapidil is effective in treating acute left heart failure and is more effective and safe than dobutamine, dopamine and furosemide in the treatment of acute left heart failure.