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对17例经逆转录聚合酶链反应(RT-PCR)法检测HGV RNA阳性的庚型肝炎患者进行临床和/或肝脏组织分析。结果发现经输血感染者8例(47.1％),散发性病例9例(52.9％)。单纯HGV感染者8例(47.1％),HGV和HBV或HCV二重、三重感染者9例(52.9％)。临床病理分型发现急性肝炎2例,慢性肝炎12例,重型肝炎2例和肝硬变1例。单纯HGV感染多呈隐匿发病,症状轻,,无黄疸,ALT轻度升高,但慢性化程度高。本文结果提示HGV感染易致病程慢性化,病理损伤轻,HGV与HBV重叠感染时,HGV有可能干扰HBV的复制。
Twenty-seven patients with HGV-RNA-positive hepatitis G were detected by reverse transcription polymerase chain reaction (RT-PCR) for clinical and / or liver tissue analysis. Results showed that 8 cases (47.1%) were infected by blood transfusion and 9 cases (52.9%) were sporadic cases. There were 8 cases (47.1%) with HGV infection alone, 2 cases with HGV and HBV or HCV, and 9 cases (52.9%) with triple infection. There were 2 cases of acute hepatitis, 12 cases of chronic hepatitis, 2 cases of severe hepatitis and 1 case of liver cirrhosis according to the clinicopathological classification. Simple HGV infection mostly occult onset, mild symptoms, no jaundice, ALT mildly elevated, but a high degree of chronic. Our results suggest that chronic infection of HGV infection prone pathology, pathological damage, HGV and HBV overlap infection, HGV may interfere with HBV replication.