论文部分内容阅读
目的研究血清游离前列腺特异抗原(FPSA)与总前列腺特异抗原(TPSA)比值对前列腺癌患者的诊断价值。方法用电化学发光免疫分析法检测54例前列腺增生(BPH),32例前列腺癌(Pca)和38例正常男性的血清FPSA、TPSA含量,并计算FPSA/TPSA比值,讨论它们对前列腺癌的诊断意义。结果单独以血清TPSA大于4.0μg/L作为前列腺癌的诊断标准,其敏感性和特异性分别为85.0%,76.2%。以FPSA/TPSA小于0.11作为前列腺癌的诊断限定值,当血清TPSA小于4.0μg/L时,FPSA/TPSA比值的敏感性和特异性分别为98.0%,68.1%;当血清TPSA大于10.0μg/L时,FPSA/TPSA比值的敏感性和特异性分别为68.5%,69.1%;而当血清TPSA在4.0￣10.0μg/L时,FPSA/TPSA比值的敏感性和特异性分别为95.3%,90.5%。结论当血清TPSA在4.0￣10.0μg/L时,FPSA/TPSA比值可大大提高前列腺癌诊断的准确率。
Objective To investigate the diagnostic value of serum free prostate specific antigen (FPSA) and total prostate specific antigen (TPSA) in patients with prostate cancer. Methods The serum levels of FPSA and TPSA in 54 cases of benign prostatic hyperplasia (BPH), 32 cases of prostate cancer (Pca) and 38 cases of normal males were detected by electrochemiluminescence immunoassay and their FPSA / TPSA ratios were calculated and their diagnostic value for prostate cancer significance. Results Serum TPSA was more than 4.0μg / L as a diagnostic criteria for prostate cancer, the sensitivity and specificity were 85.0%, 76.2%. When FPSA / TPSA was less than 0.11, the sensitivity and specificity of FPSA / TPSA ratio were 98.0% and 68.1% when serum TPSA was less than 4.0μg / L, respectively. When the serum TPSA was higher than 10.0μg / L , The sensitivity and specificity of FPSA / TPSA ratio were 68.5% and 69.1% respectively, while the sensitivity and specificity of FPSA / TPSA ratio were 95.3% and 90.5% respectively when the serum TPSA was 4.0-10.0μg / L . Conclusion When the serum TPSA is 4.0 ~ 10.0μg / L, the FPSA / TPSA ratio can greatly improve the diagnostic accuracy of prostate cancer.