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SLE是一种因B淋巴细胞超反应性而致多丙种球蛋白血症和自身抗体形成的全身性疾病。近来积累的资料认为这种免疫失常可能是由于T抑制细胞功能的缺陷而造成的。在T抑制细胞功能丧失的NZB小鼠SLE模型中一时性检出自身抗体支持了这一概念。在SLE患者身上也有相似的T抑制细胞功能障碍的报导。
SLE is a systemic disease caused by polygammaurin and autoantibodies due to B-lymphocyte hyper-reactivity. Recently accumulated data suggest that this immune disorder may be due to the T inhibition of cell function defects caused. The temporary detection of autoantibodies in the SLE model of NZB mice with suppressed T cell loss supports this concept. There are similar reports of suppression of cellular dysfunction in SLE patients.