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目的探讨急性冠状动脉综合征患者血桨蛋白Z水平及急性冠状动脉综合征高危因素与血桨蛋白Z水平的相关性研究。方法分别检测急性冠状动脉综合征患者、高胆固醇患者、高血糖患者及高低密度脂蛋白胆固醇患者血浆蛋白Z水平,并检测健康体检者血浆蛋白Z水平作为对照。结果急性冠状动脉综合征患者血浆蛋白Z水平明显下降(P<0.01),高胆固醇、高血糖、高低密度脂蛋白胆固醇患者血浆蛋白Z水平明显下降(P<0.01),与胆固醇、血糖、低密度脂蛋白胆固醇成负相关。结论急性冠状动脉综合征患者血清蛋白Z水平明显降低,高胆固醇、高血糖、高低密度脂蛋白胆固醇患者血浆蛋白Z水平明显下降,蛋白Z降低是急性冠状动脉综合征的危险因素。
Objective To investigate the relationship between plasma Z protein levels and the risk factors of acute coronary syndrome and plasma protein Z levels in patients with acute coronary syndrome. Methods Plasma protein Z levels in patients with acute coronary syndrome, patients with high cholesterol, patients with hyperglycemia and patients with high and low density lipoprotein cholesterol were measured respectively. Plasma protein Z level was measured in healthy subjects as control. Results Plasma protein Z levels were significantly decreased in patients with acute coronary syndrome (P <0.01). Levels of plasma protein Z were significantly decreased in patients with hypercholesterolemia, hyperglycemia and high-density lipoprotein cholesterol (P <0.01) Density lipoprotein cholesterol is negatively correlated. Conclusions Serum protein Z levels in patients with acute coronary syndrome are significantly lower than those in patients with high cholesterol, hyperglycemia and high and low density lipoprotein cholesterol. The protein Z level is a risk factor for acute coronary syndrome.