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目的探讨同期放化疗对儿童青少年鼻咽癌患者生活质量(QOL)的影响及其不良反应。方法通过儿童生存质量普适性核心量表(Peds QL~(TM)4.0)和儿童生存质量癌症模块量表(Peds QL~(TM)3.0)对放化疗治疗的21例儿童青少年鼻咽癌患者进行调查与评估,并对患儿治疗期间的不良反应进行统计分析。结果一定周期的放化疗后,患儿的QOL较治疗前均呈下降趋势,Peds QL~(TM)4.0中,患儿的生理功能、情感功能、学校功能3个维度总分均下降(P<0.01),以学校功能影响较为显著,而Peds QL~(TM)3.0中,疼痛、恶心、操作焦虑、认知、交流5个方面总分均下降,差异均有统计学意义(P<0.01)。放化疗的不良反应主要集中在皮肤损害、口腔黏膜损害、口干、恶心呕吐、白细胞下降等方面。结论儿童自我报告的生活质量应受到更多关注,儿童青少年鼻咽癌患者因放化疗而导致的不良反应,可显著影响其生活质量,对不良反应可采取相应措施积极预防。
Objective To investigate the effects of concurrent chemoradiotherapy on quality of life (QOL) and its adverse reactions in children and adolescents with nasopharyngeal carcinoma. Methods Twenty-one children and adolescent patients with nasopharyngeal carcinoma treated by radiotherapy and chemotherapy were enrolled in this study. The PTSQL (TM) 4.0 and Peds QLTM (TM) 3.0) Conduct investigation and evaluation, and analyze the adverse reactions during the treatment of children. Results After a certain period of radiotherapy and chemotherapy, QOL in children showed a downward trend compared with that before treatment. In Peds QL TM 4.0, the scores of physiological function, affective function and school function decreased in all three dimensions (P < 0.01), and the influence of school function was more significant. The total scores of pain, nausea, anxiety, cognition and communication in Peds QL ~ (TM) 3.0 decreased significantly (P <0.01) . Adverse reactions to chemotherapy mainly in skin damage, oral mucosal damage, dry mouth, nausea, vomiting, leukopenia and so on. Conclusion Children’s self-reported quality of life should receive more attention. Adverse reactions caused by chemotherapy and radiotherapy in children and adolescents with nasopharyngeal carcinoma can significantly affect their quality of life, and take appropriate measures to prevent adverse reactions.