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目的探讨鼻咽癌CT/MRI的临床配准方法并评价配准效果。方法8例未经治疗的鼻咽癌患者采用相同放疗体位和面罩固定方法,CT、MRI扫描后全部图像经网络传输至AcQSIM4.9.2及Pinnacle3V7.0工作站,分别由两名医师和一名物理师在AcQSIM4.9.2采用点标记法、交互法及在Pinnacle3V7.0上采用归一化互信息法来配准。采用盲法由两名医师分别在不同工作站上目测评价,评价配准结果采用四点法:极差、差、良、很好;评价配准时间采用三点法:短时(<1min)、长时(1~3min)、很长(>3min)。结果归一化互信息法较交互法、点标记法更为准确,配准速度最快。医生组较物理师配准更为准确,速度快,其中点标记法医生组较物理师配准更为准确,速度快,而归一化互信息法和交互法医生组与物理师配准准确性及速度相当。结论归一化互信息法在速度和Robust上占优势,因由软件自动配准、人为因素影响较小故适合放疗计划配准应用。
Objective To investigate the clinical registration method of nasopharyngeal carcinoma CT / MRI and to evaluate the registration effect. Methods Eight untreated patients with nasopharyngeal carcinoma received the same radiotherapy position and mask fixation method. All the images were scanned by CT and MRI and transmitted to AcQSIM4.9.2 and Pinnacle3V7.0 workstation by two doctors and one physician In the AcQSIM4.9.2 using point marking method, interactive method and Pinnacle3V7.0 using normalized mutual information method to register. Blindly by two physicians were visually assessed on different workstations, evaluation of the registration results using four points: very poor, poor, good, very good; evaluation of registration time using three points: short time (<1min) Long time (1 ~ 3min), long (> 3min). Results normalized mutual information method than the interactive method, point marking method is more accurate, the fastest registration. The physician group is more accurate and faster than the physicist. The group of point-labeled forensic physicians is more accurate and faster than the physicist. The normalized mutual information method and the interactive forensic physicists’ registration are accurate Sex and speed quite. Conclusion The normalized mutual information method is superior to Robust in speed and Robust, and is suitable for radiotherapy planning registration application due to the automatic registration of software and less influence of human factors.