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FLT3配体 (FLT3ligand,FL)是一种跨膜蛋白 ,有膜结合型和可溶型两种。虽然在机体中广泛分布 ,但其受体 FLT3却主要表达于早期的造血干细胞。 FL通过与在细胞表面的有酪氨酸激酶活性的受体结合而发挥其造血调节作用。本文对 FL的生物学作用及前景作一综述。l FL的生物学作用1 .
FLT3 ligand (FLT3ligand, FL) is a transmembrane protein, membrane-bound and soluble two. Although widely distributed in the body, but its receptor FLT3 is mainly expressed in early hematopoietic stem cells. FL exerts its hematopoietic modulation by binding to tyrosine kinase-active receptors on the cell surface. This article reviews the biological role and future of FL. The biological role of FL 1.