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异名 pifatidine acetate,TZU-0460,Altar 化学名 2-乙酰氧基-N-[3-[3-(1-哌啶基甲基)苯氧基]丙基]乙酰胺盐酸盐药效分类抗溃疡药开发单位 (日)帝国脏器上市厂商 (日)帝国脏器1986年8月药理本品为组胺H_2受体的竞争性拮抗剂。体外对离体的豚鼠右心房、大鼠子宫,以及造海登海因氏小胃的狗,都证明本品有竞争性的H_2受体拈抗作用。静注或口服本品对海登海因氏胃小狗由组胺、五肽胃泌素及卡巴胆碱引起的胃酸分
Synonyms pifatidine acetate, TZU-0460, Altar Chemical name 2-acetoxy-N- [3- [3- (1- piperidinylmethyl) phenoxy] propyl] acetamide hydrochloride Pharmacodynamic classification Anti-ulcer drug development units (days) Empire organs listed companies (days) Empire organs August 1986 pharmacology This product is histamine H 2 receptor competitive antagonist. In vitro, isolated guinea pig right atrium, rat uterus, and dogs made of Hardenne’s stomach, have proved that the product competitive H_2 receptor antagonistic effect. Intravenous or oral administration of this product on Heidenhain’s stomach dog caused by histamine, pentagastrin and carbachol-induced gastric acid