19世纪中叶德国病理学家Rudolf Virchow就已经证明恶性组织中有白细胞浸润,认为肿瘤可能源自慢性炎症[1]。近年来对癌基因和癌变多步性过程的阐明,炎症与肿瘤作为两大基本病理变化,两者之间所存在的密切联系已得到公认。据估计至少有15%的癌症是由慢性炎症发展而形成的,如慢性 Rudolf Virchow, a German pathologist in the middle of the 19th century, has demonstrated that leukocytes infiltrate malignant tissue and suggest that the tumor may have been caused by chronic inflammation [1]. In recent years, the elucidation of multi-step process of oncogenes and carcinogenesis, inflammation and tumor as the two basic pathological changes, the close relationship exists between the two has been recognized. It is estimated that at least 15% of cancers develop from chronic inflammation, such as chronic