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采用Ames试验方法，对硒多糖和亚硒酸钠的抗突变作用进行了研究。试验结果：硒多糖和亚硒酸钠在以硒浓度为0．0336～105μg／皿时，对道诺霉素致突变性的抑制率分别为27．0％～96．3％和20．1％～90．0％；对间接致突物环磷酰胺的抑制率分别为15．4％～51．1％和17.0％～47.6％。硒多糖对叠氮钠致突变的抑制率为1.7％～15．5％。表明硒多糖和亚硒酸钠对道诺霉素致突变性有明显的抑制作用，对环磷酰胺的致突变性有一定抑制作用。而硒多糖对叠氮钠致突变性的抑制作用不明显。
Ames test method was used to study the anti-mutagenic effect of selenium polysaccharide and sodium selenite. The results showed that the inhibitory rates of selenium polysaccharide and sodium selenite to daunomycin were 27.0% ~ 96.3% and 20.1% respectively when selenium concentration was 0.0336 ~ 105μg / dish % -90.0%. The inhibitory rates of indirect mutagenic cyclophosphamide were 15.4% -51.1% and 17.0% -47.6%, respectively. Selenium polysaccharide on sodium azide mutagenicity inhibition rate of 1.7% to 15.5%. Selenium polysaccharide and sodium selenite on daunomycin mutagenicity was significantly inhibited, cyclophosphamide mutagenicity has a certain inhibitory effect. The selenium polysaccharide sodium azide mutagenicity was not obvious.