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鎮痛药嗎啡以及安定药氯丙嗪均有刺激垂体促腎上腺皮貭激素释放的作用.延胡索乙素具有类似嗎啡的鎮痛作用和类似氯丙嗪的安定作用,它是否也能引起垂体促腎上腺皮貭激素的释放是本文研究的問題. 实驗用体重80—150克的雄性大白鼠,以腎上腺維生素C含量的下降做为垂体促腎上腺皮貭激素释放的指标. 給大鼠皮下注射延胡索乙素50或70毫克/公斤(有效鎮痛和安定剂量)后,腎上腺維生素C含量明显下降,說明延胡索乙素有兴奋垂体腎上腺系統的作用。給去垂体大鼠注射延胡索乙素并不能引起腎上腺維生素C含量下降,說明延胡索乙素兴奋垂体-腎上腺系統的作用在于引起垂体促腎上腺皮貭激素的分泌,而不是直接兴奋腎上腺皮貭。給大鼠注射戊巴此妥鈉40毫克/公斤,或注射去氫皮貭醇(prednisolone)15毫克/公斤后,延胡索乙索引起垂体促腎上腺皮貭激素释放的作用消失,說明延胡索乙素这一作用的部位有可能是在下视丘.
Analgesic morphine and stable drug chlorpromazine have stimulated pituitary adrenal gland hormone release.Malmitrine has analgesic effect similar to morphine and chlorpromazine stability and whether it can also cause pituitary adrenal pituitary Hormone release is the issue of this study.Experimental male rats weighing 80-150 grams, the adrenal vitamin C content decreased as an indicator of pituitary adrenalectin hormone release to the rats subcutaneous injection of tetrahydropalmatine 50 or 70 mg / kg (effective analgesic and stable dose), the adrenal vitamin C decreased significantly, indicating that tetrahydropalmatine is excited about the role of the pituitary adrenal system. The injection of tetrahydropalmatine to the pituitary gland did not result in a decrease in the content of vitamin C in the adrenal gland, indicating that the effect of tetrahydropalmatine on the pituitary-adrenal system is due to the secretion of the adrenal pituitary hormone rather than the direct excitability of the adrenal gland. Rats were injected with sodium pentobarbital 40 mg / kg, or injection of prednisolone 15 mg / kg, the corydalis induced prion secretion of pituitary hormone disappeared, indicating that tetrahydropalmatine A role of the site may be in the next hilly.