【摘 要】
：
2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethanamine is the key intermediate of Silodosin, the α1-adrenoceptor antagonist for thetreatment of benign prostatic hyperp
【机 构】
：
Department of Medicinal Chemistry,Center of Drug Discovery
论文部分内容阅读
2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethanamine is the key intermediate of Silodosin, the α1-adrenoceptor antagonist for thetreatment of benign prostatic hyperplasia. In order to obtain this intermediate, we developed a novel synthetic route by utilizing 2-nitrochlorobenzene as the starting material via O-alkylation, reduction, diazotization, acidolysis, etherification, condensation andhydrazinolysis. The highlight of this method lies on its convenience and economy in accessing this intermediate.
其他文献
Background Serum uric acid (UA), the final product of purine degradation, has been proposed to be a marker for the severity and a possible predictor of mortalit
In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiologic
Background There are few reviews on the clinical features and prognosis of young patients with papillary thyroid cancer and bilateral cervical metastases. We ha
Microscopic polyangiitis (MPA) is characterized by an inflammatory process of the vessel walls and is classified according to the smallest vessels involved. Dia
AIM: To search candidate tumor suppressor genes (TSGs) on chromosome 4Cl through detecting high loss of heterozygosity (LOH) regions in sporadic colorectal carc
AIM: To determine the prevalence of gluten sensitive enteropathy (GSE) in a large group of patients with iron deficiency anemia (IDA) of obscure origin. METHODS
AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori)eradication with emphasis on side effect profile,patient
AIM: To evaluate the feasibility and efficacy of percutaneous transhepatic lymphosonography (PTL) as a novel method for the detection of tumor lymphangiogenesis