论文部分内容阅读
近日,中国科学技术大学生命科学学院吴缅/梅一德教授研究组揭示了长片段非编码RNA通过调控肿瘤细胞瓦伯格效应促进肿瘤生长的作用机制。相关研究成果刊登在近期出版的《分子细胞》杂志上。相对于正常细胞,肿瘤细胞的代谢方式在整体上发生了改变,其中一个显著的特征是:肿瘤细胞即使在有氧状态下也优先进行糖酵解,而不是通过产能效率更高的氧化磷酸化途径为细胞生长提供能量,这就是著名的Warburg效应(由上世纪20年代德国科学家Otto Warburg首先提出,为此他在1931年获得诺贝尔生理医学奖)。虽然低氧微环境可以促进肿瘤Warburg
Recently, the research group of Professor Wu Mei / Mei Yide from the School of Life Sciences, University of Science and Technology of China revealed the mechanism of non-coding long RNAs promoting tumor growth by regulating the Waborg effect of tumor cells. Relevant research results published in the recently published “Molecular Cell” magazine. In contrast to normal cells, the metabolic changes of tumor cells have changed in general. One of the notable features is that tumor cells preferentially perform glycolysis even under aerobic conditions, rather than by more productive and more efficient production of oxidative phosphorylation Way to provide energy for cell growth, which is the famous Warburg effect (first proposed by German scientist Otto Warburg in the 1920s, for which he won the Nobel Prize in Physiology and Medicine in 1931). Although hypoxia microenvironment can promote tumor in Warburg