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[目的]探讨免疫球蛋白对west综合症患儿细胞免疫功能的调节作用。[方法]选取30例west综合症患儿为治疗组,30例west综合症患儿为对照组。治疗组应用大剂量丙种球蛋白静滴治疗,每次2.5g,每日静脉滴注1次,5～10次为1疗程,持续3个月。对照组予地塞米松0.3～0.5mg/kg(ACTH无药源),4周后改为强的松5mg,每日3次口服,4周后减去5mg,按每日5mg或隔日5mg维持。在皮质激素减量时可加用硝基安定;治疗组在治疗开始的d1、治疗结束后d2,分别检测其外周血IL-2、IgA水平,并与对照组进行比较。[结果]west综合症患儿治疗后的IL-2、IgA与治疗前比较,差异有统计学意义(P﹤0.05),west综合症患儿应用免疫球蛋白治疗后的IL-2、IgA水平与对照组比较,差异有统计学意义(P﹤0.05)。[结论]免疫球蛋白对west综合症患儿细胞免疫功能调节作用有明显影响。
[Objective] To investigate the regulatory effect of immunoglobulin on cellular immune function in children with west syndrome. [Methods] Thirty children with west syndrome were selected as treatment group and 30 children with west syndrome as control group. The treatment group with high-dose intravenous gamma globulin treatment, each 2.5g, intravenous infusion once daily, 5 to 10 times for a course of treatment for 3 months. Control group was given dexamethasone 0.3 ~ 0.5mg / kg (ACTH no drug source), 4 weeks later changed prednisone 5mg, 3 times a day orally, 4 weeks after the subtraction of 5mg, daily 5mg or 5mg every other day to maintain . In the reduction of corticosteroids can be added with nitrazepam; treatment group at the beginning of treatment d1, d2 after treatment, respectively, the level of peripheral blood IL-2, IgA levels were compared with the control group. [Results] The levels of IL-2 and IgA in children with west syndrome after treatment were significantly different from those before treatment (P <0.05). The levels of IL-2 and IgA in children with west syndrome after treatment with immunoglobulin Compared with the control group, the difference was statistically significant (P <0.05). [Conclusion] Immunoglobulin has a significant effect on the regulation of cellular immune function in children with west syndrome.