Pennsylvania大学医院,3年来用乙胺碘呋酮治疗了70例顽固持续室性快速心律失常的患者,发现该药有非常高的肺脏毒性发生率(6％)。 作者报告4例患者,应用乙胺碘呋酮治疗心律失常过程中发生肺脏毒性反应。此4例均为男性、年龄44～73岁,应用乙胺碘呋酮治疗或预防室性心功过速均获成功。乙胺碘呋酮负荷量为1,400mg, At the University Hospital, in Pennsylvania, 70 patients with refractory persistent ventricular tachyarrhythmias were treated with amiodarone for three years and found to have a very high rate of lung toxicity (6%). The authors report 4 patients, the application of amiodarone treatment of arrhythmia during lung toxicity. The four cases were male, aged 44 to 73 years, the application of amiodarone or ventricular tachyarrodynia were successful. Amiodarone loading was 1,400 mg,