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Objective: To explore the effects and the mechanism of Wuwei Dilong Decoction (五味地龙汤 Schisandra Fruit and Earthworm Decoction) for treatment of asthma. Methods: The asthma guinea pig model was established with spray of ovalbumin (OVA). Fifteen days later, the guinea pigs were administered by intra-gastric perfusion of Wuwei Dilong Decoction once a day for 8 consecutive days. Blood samples were taken for testing the total leucocytes, eosinophil (EOS), lymphocytes, interferon-γ (IFN-γ) and leukotriene B4 (LTB4). Results: In the asthma model group, the total leucocytes, EOS and lymphocytes were all increased, with significant differences as compared with the different dosage Wuwei Dilong Decoction groups (P<0.01 or P<0.05). The serum LTB4 in the asthma model group was significantly increased and IFN-γ decreased. After administration of Wuwei Dilong Decoction of the large, medium and small dosages, LTB4 decreased, while IFN-γ increased (P<0.05 or P<0.01). Conclusion: Wuwei Dilong Decoction can inhibit infiltration and diffusion of the inflammatory cells in the asthma model guinea pigs, and regulate LTB4 and IFN-γ, which is probably one of the important mechanisms of Wuwei Dilong Decoction for relieving asthma.
Objective: To explore the effects and the mechanism of Wuwei Dilong Decoction (Schisandra Fruit and Earthworm Decoction) for treatment of asthma. Methods: The asthma guinea pig model was established with spray of ovalbumin (OVA). Fifteen days later, The guinea pigs were administered by intra-gastric perfusion of Wuwei Dilong Decoction once a day for 8 consecutive days. Blood samples were taken for testing the total leucocytes, eosinophil (EOS), lymphocytes, interferon-γ (IFN-γ) and leukotriene B4 (LTB4). Results: In the asthma model group, the total leucocytes, EOS and lymphocytes were all increased, with significant differences as compared with the different dosage Wuwei Dilong Decoction groups (P<0.01 or P<0.05). The serum LTB4 in After administration of Wuwei Dilong Decoction of the large, medium and small dosages, LTB4 decreased, while IFN-γ increased (P<0.05 or P<0.01). Conclusion: Wuwei Di Long Decoction can inhibit infiltration and diffusion of the inflammatory cells in the asthma model guinea pigs, and regulate LTB4 and IFN-γ, which is probably one of the important mechanisms of Wuwei Dilong Decoction for relieving asthma.