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从哺乳动物,如牛、马等的红血球和脾、肝等脏器为出发原材料,而不同于特开昭52-25020上所介绍的用人血清蛋白质中的α-球蛋白和最终获得的分子量为5,000左右,其作用为抑制淋巴细胞增殖的免疫抑制剂。本文所介绍的免疫抑制剂物质的分子量是500～1,500之间,作用与使用目的均与上述不同。工艺中所使用的蛋白酶类系胰蛋白酶、糜蛋白酶、胃蛋白酶和溶菌酶等,也易获得。本品不但可抑制免疫反应的亢进,还具有抗炎作用,所以也被作为抗炎剂。以往的免疫抑制剂不外乎硫唑嘌呤(azathioprine)、甲氨喋呤(Methotrexate)、环磷酰胺(cyclophos phamide)、放线菌素(actinomycin)、抗淋巴细胞血清和肾上腺皮质甾类化合物等,它们用于治疗人体发生免
Starting materials such as erythrocytes, spleen, liver and other organs of mammals such as cattle and horses are different from α-globulin in human serum proteins described in JP-A-52-25020 and the molecular weight finally obtained is 5,000 or so, its role as an immunosuppressive agent to inhibit lymphocyte proliferation. The molecular weight of the immunosuppressant described in this article is between 500 and 1,500, the purpose of which is different from the above. Processes used in the proteases trypsin, chymotrypsin, pepsin and lysozyme, but also easy to get. This product not only can inhibit the immune response hyperthyroidism, also has anti-inflammatory effect, it is also used as anti-inflammatory agent. Previous immunosuppressive agents are nothing more than azathioprine, methotrexate, cyclophos phamide, actinomycin, anti-lymphocyte serum and adrenocorticosteroid compounds , They are used to treat the body’s immune system