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目的调查不同生理阶段、避孕方式、感染因素对女性阴道乳酸杆菌数量的影响。方法收集南昌大学第二附院妇产科就诊的176例妇女的主要资料并采用qPCR方法定量分析阴道分泌物中乳酸杆菌数量,分泌物涂片和革兰染色后在显微镜下观察记录其感染状态。结果非绝经期组不同年龄段乳酸杆菌数量差异无统计学意义,绝经期组乳酸杆菌数量减少;不同避孕方式组的阴道乳酸杆菌数量差异无统计学意义;细菌性阴道病和假丝酵母菌感染组阴道乳酸杆菌数量较正常组差异均有统计学意义。结论生理阶段、细菌性阴道病和假丝酵母菌感染是影响女性阴道乳酸杆菌数量的主要因素。
Objective To investigate the effects of different physiological stages, contraceptive methods and infection factors on the number of female vaginal lactobacilli. Methods The main data of 176 women attending obstetrics and gynecology department of Second Affiliated Hospital of Nanchang University were collected. The number of lactobacilli in vaginal secretions was quantitatively analyzed by qPCR method. The smear of secretions and the smear of Gram stain were observed under microscope and the infection status was recorded . Results There was no significant difference in the number of lactobacilli among different age groups in non-menopausal group, and the number of lactobacilli decreased in menopausal group. There was no significant difference in the number of lactobacilli among different contraceptive groups. Bacterial vaginosis and candida infection The number of vaginal lactobacilli than the normal group were statistically significant. Conclusion Physiological stage, bacterial vaginosis and Candida infection are the main factors affecting the number of vaginal lactobacilli in women.