论文部分内容阅读
直接将Ｎ－异丙基丙烯酰胺（ＮＩＰ）、丙烯酸和Ｎ，Ｎ′－甲叉双丙烯酰胺交联共聚合成了温度及ｐＨ值敏感水凝胶，包埋在此水凝胶中的抗结肠癌药物阿司匹林的释放随温度、介质ｐＨ值和药物制剂方式的变化而显著不同。在ｐＨ＝７．４的介质中３７℃时阿司匹林在水凝胶膜中的释放比２５℃时快，而在３７℃下ｐＨ＝７．４的介质中阿司匹林的释放比ｐＨ＝１．０快得多，后者在较长时间内仍释放一小部分，因此可将阿司匹林大部分定向到肠中释放。将膜剂改成粒剂后，可以获得较好的释放效果。
Directly N-isopropylacrylamide (NIP), acrylic acid and N, N’-methylene bisacrylamide crosslinked copolymerization temperature and pH-sensitive hydrogel embedded in this hydrogel anti-colon The release of the oncology drug aspirin is significantly different with changes in temperature, media pH, and drug formulation. Aspirin releases faster in the hydrogel membrane at 25 [deg.] C than at 25 [deg.] C in media at pH = 7.4 and releases aspirin in media at pH = 7.4 at 37 [deg.] C faster than pH = 1.0 Much more, the latter still releases a small fraction over a longer period of time, so most aspirin can be directed to the intestine for release. The film into tablets, you can get a better release.