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目的：研究丙氨瑞林对子宫内膜癌的作用及机理。方法：对诊刮确诊为子宫内膜癌的１７例患者，肌肉注射丙氨瑞林２００μｇ，每天１次×７ｄ。用药结束后３ｄ行手术治疗。检测用药前、后癌细胞有丝分裂指数（ｍｉｔｏｔｉｃ ｉｎｄｅｘ，ＭＩ）；并运用流式细胞术及透射电镜观察子宫内膜样腺癌８例用药前后癌细胞的细胞周期变化及超微结构变化。结果：内膜样腺癌１３例用药后ＭＩ下降（Ｐ＜０．０１），８例用药后癌细胞Ｓ期下降（Ｐ＜０．０５）；癌细胞中线粒体、粗面内质网等减少，核内常染色质减少，异染色质增多，核仁固缩或呈圈状。结论：丙氨瑞林短期治疗子宫内膜癌，尤其是子宫内膜样癌，可抑制癌细胞的合成代谢与分裂。
Objective: To study the effect and mechanism of ararelin on endometrial carcinoma. Methods: Seventeen patients with clinically diagnosed endometrial cancer were injected intramuscularly with 200 μg of arimirelin once daily for 7 days. After the end of 3d surgery. The mitotic index (MI) of cancer cells was detected before and after treatment. The cell cycle and ultrastructure of 8 cases of endometrial adenocarcinoma before and after treatment were observed by flow cytometry and transmission electron microscope. Results: Thirteen cases of endometrioid adenocarcinoma showed a decrease in MI (P <0.01), and the number of S phase in the eight cases decreased (P <0.05). Mitochondria and rough endoplasmic reticulum , Reduce the number of chromatin in the nucleus, heterochromatin increase, nucleolus shrinkage or ring-shaped. Conclusion: Short-term treatment of endometrial cancer with atrial serum, especially endometrial carcinoma, inhibits the synthesis and metabolism of cancer cells.