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组织因子作为因子 F /F a的细胞膜表面受体 ,是生理凝血过程中最重要的启动因子 ,许多炎性介质能诱导单核细胞、巨噬细胞、平滑肌细胞和血管内皮细胞表达组织因子。组织因子通过介导凝血激活形成血栓以及促进平滑肌细胞增殖和移行影响冠心病的发生和发展。本文对组织因子与动脉粥样硬化、血管成形术后再狭窄 ,心肌缺血及心肌缺血 -再灌注损伤等冠心病相关病理过程作一综述
Tissue factor as the cell surface receptor of factor F / F a is the most important promoter in the process of physiological coagulation. Many inflammatory mediators can induce the expression of tissue factor in monocytes, macrophages, smooth muscle cells and vascular endothelial cells. Tissue factor formation by thrombosis mediated thrombosis and promote smooth muscle cell proliferation and migration affect the occurrence and development of coronary heart disease. This review summarizes the pathological processes associated with coronary heart disease such as atherosclerosis, restenosis following angioplasty, myocardial ischemia and myocardial ischemia-reperfusion injury