胰岛素样生长因子结合蛋白5(IGFBP-5)是一种可以与胰岛素样生长因子(IGFs)结合的分泌性蛋白,其通过IGFs调节细胞的生长、分化、凋亡、黏附和运动[1]。IGFBP-5与IGFs结合可以调节IGFs与IGFⅠ型受体间的相互作用,改变其促有丝分裂效应、凋亡抑制效应和促细胞运动作用。但是,IGFBP Insulin-like growth factor binding protein 5 (IGFBP-5) is a secreted protein that binds to insulin-like growth factors (IGFs) and regulates cell growth, differentiation, apoptosis, adhesion and motility through IGFs [1]. The combination of IGFBP-5 and IGFs can regulate the interaction between IGFs and type I IGF receptors, and change the mitogenic effect, apoptosis inhibitory effect and cell-mediated motility. However, IGFBP