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目的探讨阿托伐他汀钙治疗血管性痴呆的临床疗效及安全性。方法选取我院收治的血管性痴呆患者78例,随机将其分为两组,对照组患者采取常规药物治疗,治疗组患者在此基础上加用阿托伐他汀钙治疗;比较两组患者临床治疗效果。结果治疗前,两组患者简易智能状态量表(MMSE)、日常生活能力量表(ADL)及长谷川痴呆量表(HDS)评分比较,差异无统计学意义(P>0.05);治疗后,治疗组患者的MMSE评分、ADL评分、HDS评分均优于对照组,差异有统计学意义(P<0.05)。结论阿托伐他汀钙治疗血管性痴呆的临床疗效明显,可改善患者的认知功能,提高患者生活能力和生活质量。
Objective To investigate the clinical efficacy and safety of atorvastatin calcium in the treatment of vascular dementia. Methods 78 patients with vascular dementia admitted to our hospital were randomly divided into two groups. The patients in the control group were treated with conventional drugs. The patients in the treatment group were treated with atorvastatin calcium. On the basis of clinical data, treatment effect. Results Before treatment, there was no significant difference between the two groups in MMSE, ADL and HDS scores (P> 0.05). After treatment, MMSE score, ADL score and HDS score of the treatment group were better than the control group, the difference was statistically significant (P <0.05). Conclusion Atorvastatin treatment of vascular dementia clinical significant effect, can improve patients ’cognitive function, improve patients’ living ability and quality of life.