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目的 :观察小剂量 5 氟脲嘧啶与顺铂持续输注化疗治疗中晚期食管癌的治疗效果。方法 :对 2 1例中晚期食管鳞癌患者均行右锁骨下静脉穿刺置管 ,应用英国佳士比公司生产的M 2 6、M 16微量注射泵作持续输注器 ,每日5 FU2 5 0mg/m2 及DDP6mg/m2 ,均经深静脉持续输注 ,连续 2 1d ,间隔 10d后重复第二疗程。结果 :治疗后取得6 6 .7%的有效率 ,疗效与传统FP方案相仿 ,但副作用减少。结论 :应用小剂量 5 FU与DDP持续输注化疗治疗中晚期食管癌疗效较好 ,副作用减少 ,扩大化疗适应症
Objective: To observe the effect of low-dose 5-fluorouracil and cisplatin continuous infusion chemotherapy in the treatment of advanced esophageal cancer. Methods: Twenty-one patients with advanced esophageal squamous cell carcinoma underwent a right subclavian vein catheterization. M 2 6 and M 16 micro-infusion pumps manufactured by British Christie’s Company were used as continuous infusion. Five FU 2 5 0mg / m2 and DDP6mg / m2, were continuous infusion of deep vein for 21 days, repeat the second course after 10d. Results: After treatment, the effective rate of 66.7% was obtained. The curative effect was similar to that of the traditional FP program, but the side effects were decreased. CONCLUSIONS: The use of small doses of 5 FU and continuous infusion of DDP in the treatment of advanced esophageal cancer has better curative effect, fewer side effects and more indications of chemotherapy