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目的:观察养胃颗粒联合西药对慢性胃炎患者胃黏膜的保护作用以及对表皮生长因子(EGF)和前列腺素E2(PGE2)水平的影响。方法:将80例脾虚气滞型慢性胃炎患者按随机数字表法分为对照组和治疗组各40例。对照组给予常规西药治疗,治疗组在常规治疗的基础上联合养胃颗粒进行治疗,4周后观察2组患者慢性胃炎的治疗情况。应用酶联免疫吸附法(ELISA)分别检测2组患者血清中的EGF和PGE2水平。结果:对照组总有效率为80.0%,治疗组总有效率为97.5%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组EGF、PGE2水平均较治疗前升高(P<0.05,P<0.01),治疗组EGF、PGE2与对照组比较,差异均有统计学意义(P<0.05)。结论:养胃颗粒联合西药对慢性胃炎患者的胃黏膜具有保护作用,其作用机制可能与上调EGF和PGE2的水平有关。
Objective: To observe the protective effects of Yangwei granule combined with western medicine on gastric mucosa in chronic gastritis patients and the effects on the levels of epidermal growth factor (EGF) and prostaglandin E2 (PGE2). Methods: Eighty patients with chronic gastritis of stagnation of spleen deficiency type were divided into control group and treatment group according to random number table method. The control group was given conventional Western medicine. The treatment group was treated with Yangwei Granule on the basis of routine treatment. After 4 weeks, the treatment of chronic gastritis was observed in the two groups. Serum levels of EGF and PGE2 were measured by enzyme linked immunosorbent assay (ELISA). Results: The total effective rate of the control group was 80.0%, and the total effective rate of the treatment group was 97.5%. There was significant difference between the two groups (P <0.05). After treatment, the levels of EGF and PGE2 in two groups were significantly higher than those before treatment (P <0.05, P <0.01). The difference between the two groups was statistically significant (P <0.05). Conclusion: Yangwei granule combined with western medicine has a protective effect on gastric mucosa in patients with chronic gastritis, the mechanism may be related to the level of EGF and PGE2.