目的：探讨醛氢叶酸，氟脲嘧啶配合放射治疗晚期复发直肠癌的临床疗效。方法：对３４例无法手术的直肠癌进行了放射治疗，其中１８例同时给予醛氢叶酸（ＣＦ），氟脲嘧啶（５Ｆｕ）的全身化疗（观察组），１６例为单纯放疗（对照组）。结果：放疗结束时，观察组中局部症状缓解率较对照组高，尤其对会阴区下坠疼的改善明显（Ｐ＜００５），且转移症状亦有所缓解。两组有效率分别为８３％、５０％。有显著性差异（Ｐ＜００５），完全缓解分别为２２２％、６２５％。结论：ＣＦ／５Ｆｕ配合放疗治疗晚期、复发直肠癌可提高近期疗效，尤其对于伴远外转移患者为理想、安全的治疗手段。 Objective: To investigate the clinical efficacy of leucovorin and fluorouracil combined with radiation in the treatment of advanced recurrent rectal cancer. Methods: Thirty-four cases of inoperable rectal cancer were treated with radiotherapy. Among them, 18 cases received simultaneous administration of leucovorin (CF) and 5-fluorouracil (5-Fu) systemic chemotherapy (observation group) and 16 cases received radiotherapy alone (control group). group). RESULTS: At the end of radiotherapy, the remission rate of local symptoms in the observation group was higher than that in the control group, especially in the perineum area. The improvement of falling pain was obvious (P<0. 05), and the metastasis symptoms also eased. The effective rates for the two groups were 83% and 50%, respectively. There was a significant difference (P<005), complete remission was 222%, 625%. Conclusion: CF/5Fu combined with radiotherapy for advanced and recurrent rectal cancer can improve the short-term efficacy, especially for patients with distant metastases as an ideal and safe treatment.