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目的:探讨抗双链DNA抗体、抗脂蛋白抗体和抗C1q抗体单项检测和联合检测在狼疮性肾炎诊断中的意义。方法:将77例系统性红斑狼疮患者分为A组41例(LN组)和B组36例(非LN组),比较抗双链DNA抗体、抗脂蛋白抗体和抗C1q抗体单项及联合检测与狼疮性肾炎的关系。结果:A组抗双链DNA抗体、抗脂蛋白抗体、抗C1q抗体单项和联合检测阳性率均明显高于B组(P<0.05)。3种自身抗体联合检测与单项检测比较,敏感性有所降低,但特异性明显提高。抗脂蛋白抗体、抗C1q抗体与抗双链DNA抗体诊断一致性均较好(KLPL=0.447,P<0.01;KC1q=0.436,P<0.01)。结论:抗双链DNA抗体、抗脂蛋白抗体和抗C1q抗体单项和多项联合检测有助于狼疮性肾炎早期诊断,抗脂蛋白抗体和抗C1q抗体在一定程度上可弥补抗双链DNA抗体对狼疮性肾炎诊断的不足。
Objective: To investigate the significance of anti-double stranded DNA antibody, anti-lipoprotein antibody and anti-C1q antibody single detection and combined detection in the diagnosis of lupus nephritis. Methods: Totally 77 patients with systemic lupus erythematosus (SLE) were divided into group A (n = 41) and group B (n = LN). Anti-double stranded DNA antibody, anti-lipoprotein antibody and anti- Relationship with lupus nephritis. Results: The positive rates of anti-dsDNA antibody, anti-lipoprotein antibody and anti-C1q antibody in group A were significantly higher than those in group B (P <0.05). The combination of three kinds of autoantibodies with single test, the sensitivity decreased, but the specificity was significantly improved. Anti-lipoprotein antibodies, anti-C1q antibody and anti-double-stranded DNA antibody diagnostic consistency are good (KLPL = 0.447, P <0.01; KC1q = 0.436, P <0.01). Conclusion: The combined detection of anti-dsDNA antibody, anti-lipoprotein antibody and anti-C1q antibody can be helpful for the early diagnosis of lupus nephritis. Anti-lipoprotein and anti-C1q antibodies can, to a certain extent, make up for anti-dsDNA antibody Lupus nephritis diagnostic deficiencies.