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目的探讨疏血通注射液联合阿司匹林治疗颈动脉粥样硬化(carotid atherosclerosis,CAS)的临床疗效及其对炎性细胞因子水平的影响。方法 60例CAS患者随机分为治疗组和对照组。对照组给予阿司匹林治疗,治疗组给予疏血通注射液联合阿司匹林治疗,治疗6个月后评价临床疗效。观察治疗前后血浆高敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平的变化。结果治疗组临床疗效总有效率为93.3%,显著高于对照组(63.3%),具有统计学差异(P<0.05);治疗后,治疗组hs-CRP,IL-6水平与治疗前和对照组比较明显降低(P<0.05);治疗组血脂水平与治疗前和对照组比较明显降低(P<0.05)。结论疏血通注射液联合阿司匹林治疗CAS临床疗效好,能降低炎性反应水平,值得临床推广应用。
Objective To investigate the clinical effects of Shuxuetong injection combined with aspirin in the treatment of carotid atherosclerosis (CAS) and its effect on the level of inflammatory cytokines. Methods Sixty CAS patients were randomly divided into treatment group and control group. The control group was given aspirin, and the treatment group was given Shuxuetong injection combined with aspirin. After 6 months of treatment, the clinical efficacy was evaluated. The changes of plasma high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels before and after treatment were observed. Results The total effective rate of the treatment group was 93.3%, which was significantly higher than that of the control group (63.3%) (P <0.05). After treatment, the levels of hs-CRP and IL-6 in the treatment group were significantly lower than those in the control group (P <0.05). The level of blood lipid in the treatment group was significantly lower than that before treatment and in the control group (P <0.05). Conclusion Shuxuetong injection combined with aspirin in the treatment of CAS good clinical efficacy, can reduce the level of inflammatory response, worthy of clinical application.