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观察近期复发,必须找到克服原虫复燃的方法,避免复燃与复发相混淆。现代抗疟药咯萘啶、蒿甲醚和氯喹均为杀灭血内裂殖体较好的药物,但治疗后较易复燃。作者设想联合用药可能克服此缺点。经过预试验,选用磷酸咯萘啶(基质)6 mg/kg、蒿甲醚 100 mg/kg和磷酸氯喹(基质)10 mg/kg 联合治疗3 d的方案,治疗经食蟹猴疟原虫血传感染的7只恒河猴,结果迅速清除了原虫血症,其中 5只猴追踪观察 300—400 d无复燃出现,但对胃肠道的副作用相当明显。3种抗疟药的剂量组合经过调整,试用磷酸咯萘啶(基质)6 mg/kg、蒿甲醚 10 mg/kg 和磷酸氯喹(基质)20mg/kg 联合治疗 3 d的方案,结果对 3只受试猴无明显副作用,原虫转阴后观察 180 d亦无复燃出现,而另 3只猴单用氯喹 20 mg/kg 治疗 3 d,未能完全克服复燃。结果表明,上述 3种药物联合使用可有效地清除原虫血症,制止复燃现象,也为近期复发动物模型的建立创造了条件。
To observe the recent recurrence, we must find ways to overcome the resurgence of protozoa and avoid confusion and relapse. Modern anti-malarial drugs pyronaridine, artemether and chloroquine are good drugs to kill the blood schizonts, but are more likely to relapse after treatment. The authors envisage that combination therapy may overcome this shortcoming. After pre-trial, the combination of pyrimethanil (matrix) 6 mg / kg, artemether 100 mg / kg and chloroquine phosphate (matrix) 10 mg / kg for 3 days was used to treat hematopoietic Infected seven rhesus monkeys, the results quickly cleared parasitemia, of which five monkeys follow the observation 300-400 d no recurrence, but the side effects of the gastrointestinal tract is quite obvious. The three anti-malarial dose combinations were adjusted and the combination of pyronaridine (matrix) 6 mg / kg, artemether 10 mg / kg and chloroquine phosphate (matrix) 20 mg / kg for 3 days was tested. Only the test monkey had no obvious side effects. After the protozoa were overcast, no flare was observed for 180 days, while the other three monkeys treated with chloroquine 20 mg / kg for 3 days failed to completely overcome the reignition. The results showed that the combination of the above three drugs can effectively remove parasitemia and stop the reignition, and also create conditions for the establishment of a recent animal model of relapse.