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二性霉素B作为人体全身性真菌感染治疗药物疗效较理想,但临床使用中病者多因不能耐受其不良反应而被迫中断治疗。作者将原来静滴给药途径改为雾化吸入。试治8例肺结核继发肺部真菌感染,结果5例有效;3例无效。8例中仅1例出现恶心反应,比原来给药途径的毒性反应明显减少,保证了病者安全接受治疗。
Amphotericin B as a systemic treatment of systemic fungal infections more effective, but the clinical use of patients because they can not tolerate the adverse reactions were forced to interrupt treatment. The author changed the original intravenous route to aerosol inhalation. Treatment of 8 cases of pulmonary tuberculosis secondary to pulmonary fungal infection, the results of 5 cases effective; 3 cases ineffective. Only one of the 8 patients showed nausea reaction, which markedly reduced the toxic reaction compared with the original administration route, thus ensuring the safe treatment of the patients.