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吲哚美辛的玻璃化温度约为50℃。在30℃条件下,无定形的吲哚美辛经过数周即可全部转化为晶体状态;在4℃条件下这种转晶过程可延长至6个月。提高玻璃化温度或降低贮存温度可延缓药物的晶型转化。本文报道了将不同比例的蚓供美辛和聚乙烯毗咯烷酮混合制成共沉淀物,了解蚓供美
Indomethacin has a glass transition temperature of about 50 ° C. At 30 ℃, amorphous indometacin can be completely converted to crystalline state after several weeks; this process can be extended to 6 months at 4 ℃. Increasing the glass transition temperature or lowering the storage temperature delays the crystal conversion of the drug. This paper reports that different proportions of earthworms were mixed with mepivacaine and polyvinylpyrrolidone to make coprecipitates,