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大多数用于局部点滴治疗中耳流脓的抗生素制剂对中耳和内耳具有毒性作用。中耳流脓是一种常见的临床病症,故极有必要寻找一种具有良好的抗菌作用、又对耳部毒性反应小的抗生素。Ceftazidime是第三代头孢霉素,它是一种广谱抗生素,对多种革兰氏阳性菌及革兰氏阴性菌有效,用于治疗中耳流脓效果良好。本文以22只粟鼠为实验对象,研究其局部用药对中耳及内耳是否有毒性作用。将1％Ceftazidime盐溶液中耳腔注入,其中10只注入后一周、12只注入后四周取颞骨做病理检查。结果发现,所有粟鼠无一只发生中耳粘性或脓性渗出性反应;用药后一周的标本,均显示有中耳炎症及粘膜出血、粘膜增厚、鼓膜上皮过度角化等改变,大多数标本可见有上皮下层的水
Most antibiotic agents used for local drip therapy of middle ear suppuration have toxic effects on the middle and inner ear. Middle ear suppuration is a common clinical condition, so it is very necessary to find a good antibacterial effect, but also on the ear toxicity of antibiotics. Ceftazidime, the third generation cephalosporin, is a broad-spectrum antibiotic that is effective against a wide range of Gram-positive and Gram-negative bacteria for the treatment of middle ear pus. In this paper, 22 Su mice as experimental subjects to study the local drug on the middle ear and inner ear whether toxic effects. The 1% Ceftazidime salt solution in the ear cavity injection, of which 10 after a week after injection, 12 after injection into the temporal bone four weeks for pathological examination. The results showed that none of all the mice produced a middle ear mucopurulent or purulent exudative reaction; one week after treatment, the samples showed otitis media and mucosal bleeding, mucosal thickening, tympanic membrane hyperkeratosis and other changes, the majority Specimens can be seen in the sub-epithelial water