论文部分内容阅读
介绍了3,5-吡啶二甲酸氮氧衍生物作为客体分子与主体分子酰胺大环的相互作用.通过质谱和核磁共振氢谱等实验技术研究了吡啶氮氧化物和酰胺大环化合物的结构特点对两者络合作用的影响.实验结果表明,3,5-吡啶二甲酰苄胺氮氧化物与酰胺大环化合物的络合能力最强,3,5-吡啶二甲酰丁胺氮氧化物次之,3,5-吡啶二甲酸苄酯氮氧化物最弱.酰胺大环分子的空腔越大其络合吡啶氮氧化物的能力越弱,酰胺大环上是否含有吡啶环结构对其络合氮氧化物的能力影响较小.并通过核磁实验进一步验证吡啶酰胺氮氧化合物与酰胺大环形成的[2]准轮烷分子在三氟乙酸/三乙胺的作用下能够发生解离/再组装行为.
The interaction of 3,5-pyridinedicarboxylate nitroxides as guest molecules with amide macrocycles was introduced.The structural characteristics of pyridine nitrogen oxides and amide macrocycles were studied by means of mass spectrometry and 1H NMR spectroscopy On the complexation of the two.The experimental results show that 3,5-pyridinedicarbamide nitrogen oxides and amide macrocyclic compounds the strongest complexation ability, 3,5-pyridine dicarboxamide nitrogen oxide In the second place, the benzyl 3,5-pyridinedicarboxylate oxynitride is the weakest.The larger the cavity of the amide macrocycle is, the weaker its ability to complex pyridine nitrogen oxide is, and whether the amide macrocycle contains the pyridine ring structure And its ability of complexing nitroxide has little influence on it, and the [2] quasiprotane molecule formed by picolinamide oxynitride and amide macrocycle can be further verified by NMR experiment under the action of trifluoroacetic acid / triethylamine Departure / reassembly behavior.