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目的:研制氟比洛芬压敏胶分散型贴剂并考察其体外经皮渗透性。方法:将氟比洛芬及各种促渗剂直接溶于压敏胶中制备压敏胶分散性贴剂,采用卧式双室扩散池,研究其体外经皮渗透行为。结果:由Duro-Tak 87-9301型压敏胶制备的贴刺具有较好的稳态渗透速率。5%氯酮与10%豆蔻酸异丙酯合用对氟比洛芬促渗效果明显,经皮渗透速率为(3.35±0.53)μg·cm~(-2)·h~(-1),促渗倍率达2.68倍。贴剂中氟比洛芬的含量由5%增加到10%,经皮渗透速率明显增大,含量增加到15%和20%时,渗透速率无明显变化。结论:所得处方中各因素的组合有利于氟比洛芬的经皮吸收。
Objective: To develop flurbiprofen pressure-sensitive adhesive dispersion patch and investigate its in vitro permeability. Methods: Flurbiprofen and various penetration enhancers were directly dissolved in pressure-sensitive adhesive to prepare pressure-sensitive adhesive dispersible patch. The horizontal double-chamber diffusion cell was used to study its percutaneous penetration. Results: The stabs prepared from Duro-Tak 87-9301 pressure-sensitive adhesive had a better steady-state permeation rate. The combination of 5% chlurone and 10% isopropyl myristate had a significant effect on the permeation of flurbiprofen, and the transdermal permeation rate was (3.35 ± 0.53) μg · cm -2 · h -1. Permeability rate of 2.68 times. The content of flurbiprofen in the patch increased from 5% to 10% and the transdermal permeation rate increased obviously. When the content increased to 15% and 20%, the permeation rate did not change obviously. CONCLUSIONS: The combination of various factors in the resulting prescription favors transdermal absorption of flurbiprofen.