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目的探讨低分子肝素和阿司匹林联用对急性冠状动脉综合征患者血小板活化及纤溶功能的影响。方法采用酶联免疫双抗体夹心法检测低分子肝素和阿司匹林联合治疗急性冠状动脉综合征患者血小板表面α颗粒膜蛋白(GMP140)、血管性假血友病因子(vWF)、组织纤溶酶原激活剂(tPA)、纤溶酶原激活剂抑制物1(PAI1)及D二聚体的含量变化。结果33例急性冠状动脉综合征患者经7d治疗后血浆GMP140、D二聚体和PAI1浓度显著降低(P<0.01),血浆vWF亦显著降低(P<0.05)。结论低分子肝素和阿司匹林联用可降低急性冠状动脉综合征患者血小板激活、内皮受损及血液高凝状态。
Objective To investigate the effect of low molecular weight heparin and aspirin on platelet activation and fibrinolytic function in patients with acute coronary syndrome. Methods The levels of α-granule membrane protein (GMP140), von Willebrand factor (vWF), tissue plasminogen activator (TPA), plasminogen activator inhibitor 1 (PAI1) and D dimer content changes. Results The levels of plasma GMP140, D dimer and PAI1 in 33 patients with acute coronary syndrome were significantly decreased (P <0.01) and vWF in plasma decreased significantly (P <0.05) after 7 days. Conclusions Low molecular weight heparin combined with aspirin can reduce platelet activation, endothelial dysfunction and hypercoagulability in patients with acute coronary syndrome.