目的　探讨卵巢上皮性癌中可溶性CD44标准型的检测方法及临床意义。方法　利用酶联免疫吸附试验和酶免疫化学发光方法 ,检测 41例卵巢上皮性癌、37例卵巢良性上皮性肿瘤及 30例正常妇女血清及腹水中可溶性CD44标准型、CA12 5水平 ,比较术前术后各指标的变化。结果　卵巢上皮性癌患者血清可溶性CD44标准型水平明显高于良性组及正常对照组 (P均 <0 0 1) ,正常对照组与良性组比较无差异 (P >0 0 5 ) ;卵巢上皮性癌患者血清及腹水可溶性CD44标准型水平呈正相关 ;手术切除肿瘤后 ,血清可溶性CD44标准型水平明显下降(P <0 0 1) ,复发前再次升高 ;血清可溶性CD44标准型与CA12 5呈正相关 ,与临床分期、病理学类型、组织学分级、是否有淋巴结转移无关 ;多因素生存回归分析显示术后血清可溶性CD44标准型和CA12 5水平与存活率相关 (P <0 0 5 )。结论　血清可溶性CD44标准型对鉴别卵巢肿瘤的良恶性 ,早期发现肿瘤复发有重要临床价值 Objective To investigate the detection of soluble CD44 in ovarian epithelial carcinoma and its clinical significance. Methods Serum and ascites in 41 cases of ovarian epithelial carcinoma, 37 cases of ovarian benign epithelial tumor and 30 normal women were detected by enzyme-linked immunosorbent assay and enzyme-linked immunosorbent chemiluminescence. The levels of soluble CD44, CA12 5, Postoperative changes in various indicators. Results Serum levels of soluble CD44 in patients with epithelial ovarian cancer were significantly higher than those in benign and normal controls (all P <0 01). There was no difference between normal control group and benign group (P> 0.05) Serum and ascites patients with cancer serum soluble CD44 standard level was positively correlated; after surgical resection of the tumor, the level of serum soluble CD44 standard decreased significantly (P lt; 0 01), increased again before relapse; serum soluble CD44 standard and CA12 5 was positively correlated , But not with clinical stage, pathological type, histological grade and lymph node metastasis. Multivariate survival regression analysis showed that postoperative serum levels of soluble CD44 and CA12 5 correlated with survival rate (P <0.05). Conclusions Serum soluble CD44 standard type can distinguish benign and malignant ovarian tumors, and early detection of tumor recurrence has important clinical value