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目的 探讨运动训练联合无创正压通气(NIPPV)对慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭患者肺康复的疗效.方法 稳定期COPD合并Ⅱ型呼吸衰竭患者38例,分为康复组(20例)和对照组(18例).两组患者均给予基础药物、氧疗及疾病管理等常规处理;康复组加用日间运动训练联合NIPPV.治疗前和治疗6个月评估第1秒用力呼气容积占预计值百分比(FEV1%预计值)、英国医学委员会呼吸困难量表(mMRC)评分、6-min步行距离(6MWD)及BMI.结果 随访6个月.康复组治疗后FEV1%预计值和6MWD较治疗前增高,mMRC评分较治疗前下降(P<0.05).康复组治疗后FEV1%预计值和6MWD高于对照组,mMRC评分低于对照组(P0.05).结论 运动训练联合NIPPV能有效促进COPD合并Ⅱ型呼吸衰竭患者的肺康复,提高重症COPD患者的通气功能和生活质量.“,”Objective To investigate the efficacy of exercise training combined with noninvasive positive pressure ventilation (NIPPV) in pulmonary rehabilitation of chronic obstructive pulmonary disease(COPD) patients with type Ⅱ respiratory failure.Methods A total of 38 stable COPD patients with type Ⅱ respiratory failure was divided into two groups of A(20 cases) and B(18 cases).All patients received basal drug treatment,oxygen therapy and disease management.The patients in group A additionally received exercise training combined with NIPPV.Then the percentage of predicted forced expiratory volume in one second(FEV1%pre),modified medical research council dyspnea scale(mMRC) score,six-minute walking distance(6MWD) and BMI were observed between two groups before and 6 months after treatment.Results The patients were followed up for 6 months.The FEV1%pre and 6MWD were higher and mMRC score was lower after treatment than those before treatment in group A(P<0.05).After treatment,the FEV1%pre and 6MWD were higher and mMRC score was lower in group A than those in group B(P0.05).Conclusion Exercise training combined with NIPPV can effectively improve pulmonary rehabilitation,ventilation function and quality of life in COPD patients with type Ⅱ respiratory failure.