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目的:探讨冠心病患者血清载脂蛋白(apo)A5的变化及其与血脂和脂蛋白的关系。方法:测定冠心病患者和对照者的血清TC、TG、HDL-C、LDL-C、apoA1、apoB和尿酸的水平,同时采用酶联免疫吸附法测定血清apoA5水平。按TG水平将冠心病患者又分为高TG亚组和正常TG亚组,分析比较组间apoA5的水平,并作相关性分析。结果:与对照组比较,冠心病组apoA5、HDL-C和apoA1水平明显降低(P<0.01或P<0.05);TG和尿酸水平均明显升高(P<0.01或P<0.05);apoB水平差异无统计学意义(P>0.05)。冠心病组中高TG亚组和正常TG亚组apoA5水平均低于对照组;而高TG亚组apoA5又低于正常TG亚组,且高TG亚组与对照组比较差异有统计学差异(P<0.01)。apoA5水平与TG水平呈显著负相关(r=-0.259,P=0.001);与HDL-C(r=0.18,P=0.01)呈正相关。结论:apoA5水平降低可能是冠心病的危险因素;血清apoA5水平与TG水平呈负相关,apoA5可能是TG代谢的重要调节因子之一。
Objective: To investigate the changes of serum apolipoprotein (apo) A5 in patients with coronary heart disease and its relationship with serum lipids and lipoproteins. Methods: Serum levels of TC, TG, HDL-C, LDL-C, apoA1, apoB and uric acid were measured in patients with coronary heart disease and controls. Serum apoA5 levels were measured by enzyme linked immunosorbent assay. Patients with coronary heart disease were divided into high TG subgroup and normal TG subgroup according to the level of TG. The level of apoA5 in the subgroup was analyzed and compared. Results: Compared with the control group, the levels of apoA5, HDL-C and apoA1 in CHD group were significantly lower (P <0.01 or P <0.05), the levels of TG and uric acid were significantly higher (P <0.01 or P < The difference was not statistically significant (P> 0.05). The levels of apoA5 in high TG subgroup and normal TG subgroup in CHD group were lower than those in control group, while those in high TG subgroup were lower than those in normal TG subgroup. There was significant difference between high TG subgroup and control group (P <0.01). There was a significant negative correlation between apoA5 level and TG level (r = -0.259, P = 0.001), and a positive correlation with HDL-C (r = 0.18, P = 0.01). Conclusion: ApoA5 level may be a risk factor for coronary heart disease. Serum apoA5 level is negatively correlated with TG level. ApoA5 may be one of the important regulators of TG metabolism.