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本研究证明进展期宫颈癌患者10/37例和10/46例外周血中分别存在有HPV16 E6和E7蛋白致敏的淋巴细胞,而40例献血员中分别为12.5％(5/40)和17.5％(7/40)。46例中有17例和25例分别进行了宫颈癌组织中的HPV16E6和E7基因序列检测,E6蛋白致敏淋巴细胞阳性的6例中检出与未检出E6序列的各占3例,E7蛋白致敏淋巴细胞阳性的5例中有3例未检出,有2例检出E7序列。
This study demonstrated that HPV16 E6 and E7 protein-sensitized lymphocytes were present in 10/37 and 10/46 cases of peripheral blood from patients with advanced cervical cancer, compared with 12.5% (5/40) and 17.5% (7/40). Among the 46 cases, 17 cases and 25 cases were detected HPV16E6 and E7 gene sequences in cervical cancer tissue respectively. Among the 6 cases positive for E6 protein sensitized lymphocytes, 3 cases were detected and not detected, 3 cases were E7 Three of the five positive cases of protein-sensitized lymphocytes were undetectable, and two of them detected E7 sequences.